Renal vitamins contain B vitamins and a limited dose of vitamin C to help replace losses related to dialysis in those with end stage renal disease. The B vitamins, also called the B-complex, are a combination of eight water soluble vitamins:
- thiamin (B1)
- riboflavin (B2)
- niacin (B3)
- pyridoxine (B6)
- cobalamin (B12)
- folic acid
- pantothenic acid
- biotin
B-Vitamins
B vitamins work to convert food into energy, metabolize amino acids, fatty acids and glucose, help with production new cells and protect nerve fibers.
Folate, vitamin B6 and vitamin B12 are especially important for red blood cell production. In people with kidney failure, deficiencies result in anemia that does not improve with iron and erythropoietin (Epogen) therapy. These vitamins are also needed to help build red blood cells. The right balance of these of vitamins is important for dialysis patients. Taking a folic acid supplement without vitamin B12 can hide a B12 deficiency and cause permanent nerve damage. Mega doses of vitamin B6 over time can also cause nerve damage.
Vitamin C
Vitamin C forms collagen, works as an antioxidant that protects cells from damage, helps the immune system, and is required for making many body compounds. Most renal vitamins contain 60 to 100 milligrams of vitamin C. Larger doses of vitamin C from supplements are not recommended for those with kidney failure because it increases the risk for oxalate deposits and kidney stones.
Before using high doses of supplements, talk with your doctor or dietitian about the right renal vitamin for you. Too much of anything tends to not be healthy.
Reference:
Malouf R, Grimley Evans J. Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people. Cochrane Database Syst Rev. 2008 Oct 8;2008(4) https://pmc.ncbi.nlm.nih.gov/articles/PMC12926861/. Accessed September 4, 2026.
